Which is the most serious adverse drug effect of ketoconazole?
Ketoconazole can cause serious harm to your liver that may result in liver transplant or cause death. Call your doctor at once if you have any signs of liver damage, such as nausea, vomiting, stomach pain, fever, tiredness, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
What are the contraindications of ketoconazole?
Who should not take KETOCONAZOLE?
- decreased function of the adrenal gland.
- torsades de pointes, a type of abnormal heart rhythm.
- prolonged QT interval on EKG.
- abnormal EKG with QT changes from birth.
- absence of stomach acid.
- damage to the liver and inflammation.
- abnormal liver function tests.
What is the black box warning for ketoconazole?
The US Food and Drug Administration (FDA) is warning clinicians against the off-label prescribing of ketoconazole tablets (Nizoral, Janssen Pharmaceuticals) to treat skin and nail fungal infections because the risk for serious liver damage and death outweighs the benefits.
Which is not the side effects of griseofulvin?
Headache, nausea, vomiting, diarrhea, stomach upset, tiredness, dizziness, or trouble sleeping may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
What is a common concern when using Jublia?
The most common side effects (around 2% of patients) in clinical trials were ingrown toenail, redness, itching, swelling, burning or stinging, blisters, and pain. JUBLIA may cause other side effects.
What drugs interact with ketoconazole?
Ketoconazole interacts with drugs such as cisapride, disopyramide, dofetilide, dronedarone, methadone, pimozide, quinidine, ranolazine, among others. These interactions may increase the risk of a certain condition that affects the heart rhythm (QT prolongation).
Is ketoconazole toxic?
Ketoconazole may cause liver damage, sometimes serious enough to require liver transplantation or to cause death. Liver damage may occur in people who do not already have liver disease or any other conditions that increase the risk that they will develop liver damage.
Can you use too much ketoconazole?
Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.
Is ketoconazole bad?
In a July 2013 Drug Safety Communication, we warned that ketoconazole tablets should not be used as a first-line treatment for any fungal infection because it can cause severe liver injury and adrenal gland problems, and advised it can lead to harmful interactions with other medicines.
What is the most common side effect of griseofulvin?
The more common side effects of griseofulvin can include: rash. numbness or tingling in your hands or feet. yeast infections in your mouth.
